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. 2019 Jan 11;9:57. doi: 10.1038/s41598-018-37312-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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5xFAD and 3xTG mice have impairments in object-based memory tasks. Schematic representations of the (a) Y-apparatus OR, (b) open-field OR, and (c) OL tasks. (d) 5xFAD mice were impaired on Y-apparatus OR (Wt male n = 11, Wt female n = 8, 5xFAD male n = 10, 5xFAD female n = 11; significant main effects of genotype (F_1,36 = 19.198, p < 0.001) and delay (F_1,36 = 9.560, p = 0.004), as well as a genotype x delay interaction (F_1,36 = 8.563; p = 0.006) were observed), (e) open-field OR (Wt male n = 11, Wt female n = 8, 5xFAD male n = 10, 5xFAD female n = 11; significant main effects of genotype (F_1,32 = 6.392, p = 0.017) and delay (F_1,32 = 22.725, p < 0.001), as well as a genotype x delay interaction (F_1,32 = 7.791, p = 0.009) were found) and (f) OL (Wt male n = 15, Wt female n = 12, 5xFAD male n = 10, 5xFAD male n = 10; a significant main effect of genotype was found (F_1,43 = 20.451, p < 0.001) at both 5 min and 3 h retention delays. 3xTG mice had more selective memory impairments. (g) 3xTG mice were impaired on Y-apparatus OR at the 3 h, but not 5 min, delay (Wt male n = 11, Wt female n = 12, 3xTG male n = 7, 3xTG female n = 10; significant main effects of genotype (F_1,36 = 26.260, p < 0.001) and delay (F_1,36 = 19.172, p < 0.001), as well as a genotype x delay interaction (F_1,36 = 21.012, p < 0.001) were observed). (h) 3xTG males were impaired on open-field OR at both the 5 min and 3 h delays, whereas females were only impaired at the 3 h delay (Wt male n = 11, Wt female n = 12, 3xTG male n = 7, 3xTG female n = 12; significant main effects of genotype (F_1,36 = 26.260, p < 0.001) and delay (F_1,36 = 19.172, p < 0.001), as well as a genotype x delay interaction (F_1,36 = 21.012, p < 0.001) were demonstrated). (i) 3xTG mice were also impaired on OL at both delays (Wt male n = 12, Wt female n = 15, 3xTG male n = 14, 3xTG female n = 15; significant main effects of genotype (F_1,51 = 43.417, p < 0.001) and delay (F_1,51 = 16.387, p < 0.001) were found).Data are mean discrimination ratio ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 indicates significant differences between sample and choice DR, suggesting intact memory (paired-sample t-tests, two-tailed). ^††p < 0.01, ^†††p < 0.001 indicates a significant overall difference between Wt and 5xFAD or 3xTG mice (independent samples t-test, two-tailed, Bonferroni correction).