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. 2019 Jan 11;9:62. doi: 10.1038/s41598-018-37303-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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At all ages tested, an effect of genotype (Two-Way ANOVA, p < 0.001, P40: F(2,100) = 9.791, P100: F(2,100) = 16.886, P180: F(2,84) = 10.595) and an effect of arm level (Two-Way ANOVA, p < 0.001, P40: F(3,100) = 221.487, P100: F(3,100) = 203.358, P180: F(3,84) = 158.430) were detected for the number of arm entries. A post hoc Holm-Sidak method revealed an higher number of total entries (TOT) scored for nes-CrT^−/y mice (post hoc Holm-Sidak method, P40: p < 0.001 vs. CrT^+/y, p < 0.01 vs. nes-CrT^+/y; P100 and P180: p < 0.001 for both comparisons; Fig. 3a–c left side). In contrast, no difference was found in the number of entries in the single arms of the maze (A, B, C; Two-Way ANOVA, post hoc Holm-Sidak method), excluding a specific bias in arm choice. No difference in the Y maze performance was present among the three groups tested at P40 (CrT^+/y, n = 13, nes-CrT^+/y, n = 9, nes-CrT^−/y, n = 6; One Way ANOVA, p = 0.417, F(2,25) = 0.906, panel a right side). In contrast, spontaneous alternation rate was significantly lower in nes-CrT^–/y mice compared to that recorded for CrT^+/y animals and nes-CrT^+/y littermates at P100 (One Way ANOVA, p < 0.01, F(2,25) = 6.599, post hoc Holm-Sidak method, p < 0.05 vs. CrT^+/y, p < 0.01 vs. nes-CrT^+/y; panel b right side) and P180 (CrT^+/y, n = 9, nes-CrT^+/y, n = 9, nes-CrT^−/y, n = 6; One Way ANOVA, p < 0.05, F(2,21) = 4.766, post hoc Holm-Sidak method, p < 0.05 for both comparisons; panel c right side). Symbols refer to post-hoc Holm Sidak comparisons between nes-CrT^−/y mice and the genotype corresponding to the column on which the symbol is located: *p < 0.05, ^#p < 0.01. Error bars, s.e.m.