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. 2019 Jan 1;10(1):131–137. doi: 10.7150/jca.28216

Table 2.

Meta-analysis results of the relationship between PBK/TOPK protein and OS.

Group/ subgroup No. of data set No. of cases Pooled HR (95%CI) p-value Model Phet I² (%)
Overall 10-29 20 3470 1.69 (1.33-2.04) <0.001 Random 71.7 0.0
Lung cancer 12, 18, 19, 21 4 728 2.30 (1.79-2.81) <0.001 Fixed 0.524 0.0
Prostate cancer 14, 28 2 226 1.61 (0.12-3.10) NS Fixed 0.853 0.0
Gastric carcinoma 15, 26, 27 3 608 1.13 (0.86-1.41) NS Fixed 0.141 49
Colorectal cancer 10, 22, 25 3 353 2.39 (1.81-2.97) <0.001 Fixed 0.643 0.0
European cohorts 10, 20, 28 3 505 2.08 (0.94-3.23) NS Fixed 0.593 0.0
Asia cohorts 11-19, 21-27, 29 17 2965 1.65 (1.28-2.03) <0.001 Random 0.000 74.9
Multivariate analysis 10-13, 15, 17-24, 27-29 16 3050 1.88 (1.42-2.34) <0.001 Random 0.000 77.0