Table 4.
Association between SMUG1 rs3087404 and rs2029167 polymorphisms with the risk of HR-HPV positive cervical carcinoma and CIN III
| SMUG1 Genotypes | HPV-positive patients and controls | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control N=191 |
CIN III N=310 |
adjusted OR*(95% CI) | P | carcinoma N=178 |
adjusted OR*(95% CI) | P | |||||||
| N | % | N | % | n | % | ||||||||
| rs3087404 | |||||||||||||
| AA | 65 | 34.0 | 111 | 35.8 | 1.00(ref) | 49 | 27.5 | 1.00(ref) | |||||
| AG | 103 | 53.9 | 143 | 46.1 | 0.81(0.55-1.21) | 0.307 | 61 | 34.3 | 0.79(0.48-1.28) | 0.332 | |||
| GG | 23 | 12.0 | 56 | 18.1 | 1.43(0.80-2.53) | 0.226 | 68 | 38.2 | 3.91(2.15-7.15) | 0.000 | |||
| AG+GG | 126 | 66.0 | 199 | 64.2 | 0.93(0.63-1.35) | 0.686 | 129 | 72.5 | 1.36(0.87-2.12) | 0.177 | |||
| Allelic frequency | |||||||||||||
| Allele A | 233 | 61.0 | 365 | 58.9 | 1.00(ref) | 159 | 44.7 | 1.00(ref) | |||||
| Allele G | 149 | 39.0 | 255 | 41.1 | 1.09(0.84-1.42) | 0.506 | 197 | 55.3 | 1.94(1.45-2.60) | 0.000 | |||
| rs2029167 | |||||||||||||
| AA | 71 | 37.2 | 92 | 29.7 | 1.00(ref) | 42 | 23.6 | 1.00(ref) | |||||
| AG | 83 | 43.5 | 103 | 33.2 | 0.96(0.63-1.46) | 0.841 | 51 | 28.7 | 1.04(0.62-1.74) | 0.885 | |||
| GG | 37 | 19.4 | 115 | 37.1 | 2.40(1.48-3.89) | 0.000 | 85 | 47.8 | 3.88(2.26-6.88) | 0.000 | |||
| AG+GG | 120 | 62.8 | 218 | 70.3 | 1.40(0.96-2.05) | 0.083 | 136 | 76.4 | 1.92(1.22-3.02) | 0.005 | |||
| Allelic frequency | |||||||||||||
| Allele A | 225 | 58.9 | 287 | 46.3 | 1.00(ref) | 135 | 37.9 | 1.00(ref) | |||||
| Allele G | 157 | 41.1 | 333 | 53.7 | 1.66(1.29-2.15) | 0.000 | 221 | 62.1 | 2.35(1.75-3.15) | 0.000 | |||
Bold values show statistical data with significant difference. *All P-values are adjusted for age, number of sexual partners, age at first intercourse, parities (including full-term pregnancy and abortion at or after 28 weeks) and age at first full-term pregnancy.