Table 5.

Association between SMUG1 rs3087404 polymorphisms and the risk for CIN III and cervical carcinoma stratified by the sexual, reproductive history

High risk exposure		Controls						χ2	P	CIN III						χ2	P	Carcinoma						χ2	P
		AA		AG		GG				AA		AG		GG				AA		AG		GG
		N	%	N	%	N	%			N	%	N	%	N	%			N	%	N	%	N	%
Age
	≤ 40	212	35.2	323	53.7	67	11.1	0.036	8.490	93	36.0	120	46.5	45	17.4	0.837	0.360	44	27.5	61	38.1	55	34.4	0.000	0.991
	>40	202	33.8	336	56.2	60	10.0			48	33.8	62	43.7	32	22.5			69	28.8	86	35.8	85	35.4
Number of sexual partners
	≤ 1	321	33.3	538	55.9	104	10.8	2.590	0.108	120	38.0	151	47.8	45	14.2	15.610	0.000	93	30.1	126	40.8	90	29.1	13.468	0.000
	>1	93	39.2	121	51.1	23	9.7			21	25.0	31	36.9	32	38.1			20	22.0	21	23.1	50	54.9
Age at the first intercourse
	≤20	122	34.0	187	52.1	50	13.9	1.364	0.243	32	24.6	57	43.8	41	31.5	18.453	0.000	26	20.8	36	28.8	63	50.4	15.528	0.000
	>20	292	34.7	472	56.1	77	9.2			109	40.4	125	46.3	36	13.3			87	31.6	111	40.4	77	28.0
Number of parities
	≤ 3	184	33.6	299	54.6	65	11.9	1.055	0.304	51	32.3	74	46.8	33	20.9	1.094	0.296	34	26.0	52	39.7	45	34.4	0.069	0.792
	>3	230	35.3	360	55.2	62	9.5			90	37.2	108	44.6	44	18.2			79	29.4	95	35.3	95	35.3
Age at the first parity
	≤22	84	35.7	131	55.7	20	8.5	0.675	0.411	31	34.1	43	47.3	17	18.7	0.014	0.905	22	24.7	36	40.4	31	34.8	0.183	0.669
	>22	330	34.2	528	54.7	107	11.1			110	35.6	139	45.0	60	19.4			91	29.3	111	35.7	109	35.0
HR-HPV infection status
	Positive	65	34.0	103	53.9	23	12.0	0.595	0.440	111	35.8	143	46.1	56	18.1	0.176	0.675	49	27.5	61	34.3	68	38.2	0.017	0.895
	Negative	151	36.1	227	54.3	40	9.6			16	34.0	21	44.7	10	21.3			6	26.1	9	39.1	8	34.8

Bold values show statistical data with significant difference. Stratified analysis were applied by the Kruskal-Wallis H. A p value less than 0.05 was considered significant.