Table 8.
Genotypes and the risk of all CIN III and cervical carcinoma subjects
| SMUG1 Genotypesa | All patients and controls | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | CIN III | adjusted ORb(95% CI) | P | Carcinoma | adjusted ORb(95% CI) | P | |||||
| 1200 | 400 | 400 | |||||||||
| N | % | N | % | N | % | ||||||
| AA-AA | 158 | 13.2 | 39 | 9.8 | 1.00(ref) | 19 | 4.8 | 1.00(ref) | |||
| AA-AG | 172 | 14.3 | 37 | 9.3 | 0.87(0.53-1.44) | 0.589 | 22 | 5.5 | 1.06(0.56-2.04) | 0.853 | |
| AA-GG | 84 | 7.0 | 65 | 16.3 | 3.14(1.95-5.05) | 0.000 | 72 | 18.0 | 7.13(4.03-12.61) | 0.000 | |
| AG-AA | 239 | 19.9 | 50 | 12.5 | 0.85(0.53-1.35) | 0.485 | 18 | 4.5 | 0.63(0.32-1.23) | 0.174 | |
| AG-AG | 291 | 24.3 | 53 | 13.3 | 0.74(0.47-1.17) | 0.192 | 17 | 4.3 | 0.49(0.25-0.96) | 0.038 | |
| AG-GG | 129 | 10.8 | 79 | 19.8 | 2.45(1.58-3.89) | 0.000 | 112 | 28.0 | 7.22(4.21-12.38) | 0.000 | |
| GG-AA | 58 | 4.8 | 32 | 8.0 | 2.24(1.28-3.90) | 0.005 | 60 | 15.0 | 8.60(4.73-15.63) | 0.000 | |
| GG-AG | 69 | 5.8 | 44 | 11.0 | 2.58(1.54-4.32) | 0.027 | 80 | 20.0 | 9.64(5.43-17.13) | 0.000 | |
| GG-GG | 0 | 0.0 | 1 | 0.3 | _ | _ | 0 | 0.0 | _ | _ | |
Bold values show statistical data with significant difference. agenotypes are composed of two polymorphic sites: rs3087404(A/G), rs2029167(A/G). bAll P-values are adjusted for age, number of sexual partners, age at first intercourse, parities (including full-term pregnancy and abortion at or after 28 weeks) and age at first full-term pregnancy.