Figure 1.

Histopahtology of SCCOHT. The large tumor has a fleshy white to grey appearance with extensive hemorrhage, necrosis and cystic degeneration (A). Microscopically, the tumor has a diffuse growth pattern consisting of closely packed small cells and focal areas of follicle-like spaces containing eosinophilic fluids [Figure 1B]. The large cells characteristically show “rhabdoid” features with eccentric nuclei, prominent nucleoli and glassy eosinophilic cytoplasm [Figure 1C]. The cancer cells are negative for BRG1 immunostaining while the lymphocytes have a retained BRG1 staining [Figure 1D].