Table 2.
Logistic regression analysis for predicting TIMT4 according to clinicopathological characteristics
| High PD-L1/High CD8+ TIL | High PD-L1/High CD8+ TIL | ||||
|---|---|---|---|---|---|
| OR | P | OR | P | ||
| age | >65y | 1.32 (1.007-1.729) | 0.044 | 1.172 (0.907-1.513) | 0.224 |
| gender | female | 1.45 (1.112-1.891) | 0.006 | 1.549 (1.201-1.998) | 0.001 |
| histology | SCC | 0.838 (0.645-1.090) | 0.188 | 0.897 (0.699-1.151) | 0.391 |
| smoking history | smoker | 0.809 (0.514-1.273) | 0.35 | 0.846 (0.545-1.313) | 0.455 |
| EGFR | mutant | 0.52 (0.285-0.951) | 0.031 | 0.45 (0.256-0.790) | 0.005 |
| KRAS | mutant | 1.045 (0.737-1.486) | 0.801 | 1.094 (0.780-1.528) | 0.596 |
| T stage | T3-4 | 0.883 (0.609-1.282) | 0.514 | 0.815 (0.572-1.160) | 0.256 |
| N stage | N1-2 | 0.996 (0.748-1.326) | 0.98 | 0.93 (0.708-1.220) | 0.599 |
| M stage | M1-2 | 0.522 (0.211-1.291) | 0.159 | 0.466 (0.206-1.057) | 0.068 |
| TMB | >median | 1.191 (0.911-1.558) | 0.202 | 1.122 (0.869-1.447) | 0.377 |
| IFNγ expression | >median | 13.581 (9.542-19.33) | <0.001 | 13.296 (9.752-18.128) | <0.001 |
OR, odds ratio; PD-1, programmed cell death-1; PD-L1, programmed cell death ligand-1; SCC, squamous cell carcinoma; EGFR, epidermal growth factor receptor; KRAS, Kirsten rat sarcoma viral oncogene.