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. 2019 Jan 1;10(1):43–50. doi: 10.7150/jca.26723

Figure 4.

Figure 4

Further validation of tumor-derived circulating miR-1290 and miR-320d as novel biomarkers for early diagnosis of CRC. A-B. Tissue miR-1290 and miR-320d were significantly dysregulated in both adenoma and CRC patients. C-D. The expression of miR-1290 and miR-320d returned to normal levels after surgical resection of malignancies. E-F. The positive correlation of miR-1290 and miR-320d expression levels between matched primary CRC tissues and plasma samples. G-H. Plasma miR-1290 and miR-320d were significantly dysregulated in both adenoma and CRC patients. I-J. The diagnostic utility of plasma miR-1290 and miR-320d to distinguish adenoma and CRC patients from healthy controls. *P<0.05, **P<0.01, ***P<0.001.