TABLE IV.

Impact of Combined BCP and PC Mutations on HBeAg Titers

Group	Sequence	Number	HBeAg titer (S/CO)a	HBV DNAb
A	Wild-type	74	228.5 ± 81.4	7.27 ± 0.84
B	PC mutation alone	30	192.2 ± 96.7	6.91 ± 0.83
C	BCP mutations alone	90	185.6 ± 88.7	7.16 ± 0.95
D	BCP + PC mutations	13	78.9 ± 89.2	7.03 ± 1.04

P values (HBeAg titers): A/B, 0.019; A/C, 0.0001; A/D, 0.0000; B/C, 0.552; B/D, 0.0008; C/D, 0.0003.

P values (HBV DNA): A/B, 0.132; A/C, 0.446; A/D, 0.363; B/C, 0.326; B/D, 0.915; C/D, 0.627.

^aExpressed as X ± SD.

^blog₁₀ copies/ml