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. 2019 Jan 6;15(1):81–92. doi: 10.7150/ijbs.28304

Figure 4.

Figure 4

G1 activates PI3K-Akt-mTOR signaling pathway in cardiomyocytes. (A-D) Western blot and quantitative analysis of cardiac mTOR, S6K1, Akt, 4EBP expression. (E) Expression of Akt protein in cardiomyocytes stimulated by G1 at different time. Data are expressed as the mean±SEM (n=3). **P<0.01 versus control, #P<0.05 versus Ang II, ##P<0.01 versus Ang II, △P<0.05 versus Ang II+G1, △△P<0.01 versus Ang II+G1. mTOR: mammalian target of rapamyein, S6K1: p-ribosomal protein S6 kinase, Akt: protein kinase B, 4EBP: p4E binding protein 1, G1: a GPER1 agonist, G15: GPR30 antagonist, Ang II: angiotensin II.