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. 2019 Jan 1;15(1):183–194. doi: 10.7150/ijbs.29203

Figure 1.

Figure 1

PSPH is overexpressed in NSCLC and correlated with advanced clinical stage and tumor invasion and metastasis. A. The expression levels of PSPH in 73 paired NSCLC and corresponding noncancerous tissues were measured by qRT-PCR analysis and β-Actin was used as the internal reference gene. B. Overexpression of PSPH mRNA was observed in 65.8% of the NSCLC compared with the corresponding non-cancerous tissues. C. PSPH mRNA was overexpressed in NSCLC tissues compared with the noncancerous tissues (P value =0.0003). D. The up-regulation of PSPH mRNA in NSCLC was associated with tumor metastasis (P value =0.039). The patients were classified into tumor metastasis negative and positive groups (lymph node metastasis and/ or distal metastasis). E. PSPH mRNA expression was detected in different clinical stages of NSCLC (P value =0.004). F. Kaplan-Meier analyses of the correlation between PSPH mRNA levels and overall survival in the 117-patient-GEO cohort (P value =0.025). G. The expression of PSPH protein was detected in paired NSCLC and corresponding noncancerous tissues (T is the abbreviation tumor tissue, N is the abbreviation for noncancerous tissue). H. Overexpression of PSPH protein was observed in NSCLC tissues (P value =0.0003). Error bars represent SD (standard deviation). The statistical analysis was performed using paired t-test for C and H, and Student's t-test for D and E.