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PSPH regulates the ERK MAPK and P38 MAPK signaling pathways. Western blot analysis of p-MEK, MEK, p-ERK, ERK, p-P38 and P38 in PC9 and H1299 cells transfected with si-NC and si-PSPH. Data are expressed as the mean ± SEM. **P<0.01 and ***P<0.001 by Student's t-test.