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A schematic model of EGFRvIII's reverse nuclear trafficking: after endocytosis, EGFRvIII is recognized, submitted and transported to trans Golgi by syntaxin6; COPI mediates the shuttle of EGFRvIII on Golgi apparatus and the retrograde trafficking from Golgi to ER; Finally, EGFRvIII is transported to the nucleus; EGFRvIII's nuclear translocation can increase the phosphorylation of STAT3 and promote the nuclear localization of PKM2.
