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. 2019 Jan 1;15(1):239–252. doi: 10.7150/ijbs.29063

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Hyperglycemia induced renal fibrosis in T1D mice at six months. (A) Fibrosis markers mRNA, including TGF-β, FN, collagen I, and collagen IV were examined by RT-PCR and quantified; (B) Protein levels of TGF-β, CTGF, collagen I, collagen IV, laminin and FN were measured by Western blot and quantified. (C) FN expression of Ctrl and T1D mice measured by Western blot and quantification analysis at three and six months. Data are represented as mean ± SD (n = 5 in each group, * p < 0.05, vs Ctrl; #p < 0.05, vs DM).

Hyperglycemia induced renal fibrosis in T1D mice at six months. (A) Fibrosis markers mRNA, including TGF-β, FN, collagen I, and collagen IV were examined by RT-PCR and quantified; (B) Protein levels of TGF-β, CTGF, collagen I, collagen IV, laminin and FN were measured by Western blot and quantified. (C) FN expression of Ctrl and T1D mice measured by Western blot and quantification analysis at three and six months. Data are represented as mean ± SD (n = 5 in each group, * p < 0.05, vs Ctrl; #p < 0.05, vs DM).