Table 1.
List of the potential miRNA targets among differentially expressed proteins in VPA treated LX2 cells.
| Symbol | Entrez Gene Name | Location | Type(s) | Fold- Change | Number of miRNAs | Targeted by miRNAs |
|---|---|---|---|---|---|---|
| AHSG | alpha 2-HS glycoprotein | Extracellular Space | other | 2.4862 | 3 | hsa-miR-100-3p, hsa-miR-27a-3p, hsa-miR-335-5p |
| ALB | albumin | Extracellular Space | transporter | 1.5721 | 2 | hsa-miR-100-3p, hsa-miR-143-3p |
| ALCAM | activated leukocyte cell adhesion molecule | Plasma Membrane | other | 1.4458 | 7 | hsa-miR-148b-3p, hsa-miR-18a-5p, hsa-miR-27a-3p, hsa-miR-34a-5p, hsa-miR-376c, hsa-miR-192-5p, hsa-miR-532-3p |
| ANXA11 | annexin A11 | Nucleus | other | 1.4247 | 3 | hsa-miR-99b-3p, hsa-miR-195-5p, hsa-miR-7-5p |
| ANXA2 | annexin A2 | Plasma Membrane | other | 1.8081 | 3 | hsa-miR-425-5p, hsa-miR-29a-3p, hsa-miR-1275 |
| ANXA6 | annexin A6 | Plasma Membrane | ion channel | 1.4183 | 1 | hsa-miR-324-3p |
| ATP2B4 | ATPase plasma membrane Ca2+ transporting 4 | Plasma Membrane | transporter | 1.4283 | 6 | hsa-miR-148b-3p, hsa-let-7c, hsa-miR-99b-3p, hsa-miR-99a-5p, hsa-miR-135b-5p, hsa-miR-29a-3p |
| BAG3 | BCL2 associated athanogene 3 | Cytoplasm | other | 0.6526 | 1 | hsa-miR-29a-5p |
| BID | BH3 interacting domain death agonist | Cytoplasm | other | 1.4442 | 1 | hsa-miR-26a-5p |
| C12orf75 | chromosome 12 open reading frame 75 | Other | other | 1.4737 | 4 | hsa-miR-130a-3p, hsa-miR-136-3p, hsa-miR-656, hsa-miR-1275 |
| CD47 | CD47 molecule | Plasma Membrane | transmembrane receptor | 1.6693 | 6 | hsa-miR-15a-3p, hsa-miR-376a-3p, hsa-miR-15b-3p, hsa-miR-34a-5p, hsa-miR-155-5p, hsa-miR-376c |
| COPS7B | COP9 signalosome subunit 7B | Cytoplasm | other | 1.3612 | 3 | hsa-miR-195-5p, hsa-miR-34a-5p, hsa-miR-27a-5p |
| CUL1 | cullin 1 | Nucleus | enzyme | 0.6838 | 1 | hsa-miR-500a-5p |
| GPRC5A | G protein-coupled receptor class C group 5 member A | Plasma Membrane | G-protein coupled receptor | 1.7744 | 4 | hsa-miR-148b-3p, hsa-miR-143-3p, hsa-miR-31-5p, hsa-miR-532-3p |
| HECTD1 | HECT domain E3 ubiquitin protein ligase 1 | Other | enzyme | 1.4358 | 4 | hsa-miR-142-3p, hsa-miR-195-5p, hsa-miR-130a-3p, hsa-miR-532-3p |
| HLA-B | major histocompatibility complex, class I, B | Plasma Membrane | transmembrane receptor | 1.3912 | 2 | hsa-miR-148b-3p, hsa-miR-222-5p |
| HMGA1 | high mobility group AT-hook 1 | Nucleus | transcription regulator | 2.1562 | 8 | hsa-miR-25-5p, hsa-miR-142-3p, hsa-let-7c, hsa-miR-195-5p, hsa-miR-26a-5p, hsa-miR-103a-3p, hsa-miR-1275, hsa-miR-197-3p |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | Nucleus | enzyme | 1.3736 | 10 | hsa-miR-195-5p, hsa-miR-27a-3p, hsa-miR-135b-5p, hsa-miR-218-5p, hsa-miR-34a-5p, hsa-miR-30b-5p, hsa-miR-411-5p, hsa-miR-616-3p, hsa-miR-149-5p, hsa-miR-532-3p |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | Nucleus | other | 1.5216 | 5 | hsa-miR-103a-3p, hsa-miR-186-5p, hsa-miR-195-5p, hsa-miR-30b-5p, hsa-miR-335-5p |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | Nucleus | other | 1.4076 | 1 | hsa-miR-30b-5p |
| HSBP1 | heat shock factor binding protein 1 | Nucleus | other | 1.4140 | 2 | hsa-miR-374a-5p, hsa-miR-145-5p |
| KRT10 | keratin 10 | Cytoplasm | other | 2.0699 | 1 | hsa-miR-142-3p |
| LUC7L | LUC7 like | Nucleus | other | 0.6989 | 1 | hsa-miR-361-5p |
| MFAP1 | microfibril associated protein 1 | Extracellular Space | other | 0.6611 | 1 | hsa-miR-589-3p |
| MYL12A | myosin light chain 12A | Cytoplasm | other | 0.6875 | 1 | hsa-miR-154-3p |
| MYL12B | myosin light chain 12B | Cytoplasm | other | 1.4995 | 3 | hsa-miR-27a-5p, hsa-miR-1275, hsa-miR-7-5p |
| MYO1E | myosin IE | Cytoplasm | enzyme | 1.5002 | 2 | hsa-miR-324-3p, hsa-miR-155-5p |
| NUDT15 | nudix hydrolase 15 | Cytoplasm | phosphatase | 1.3561 | 5 | hsa-miR-25-5p, hsa-miR-425-3p, hsa-let-7c, hsa-miR-192-5p, hsa-miR-1275 |
| NUP133 | nucleoporin 133 | Nucleus | transporter | 0.6376 | 1 | hsa-miR-935 |
| NUP85 | nucleoporin 85 | Cytoplasm | other | 1.4921 | 1 | hsa-miR-218-5p |
| OS9 | OS9, endoplasmic reticulum lectin | Nucleus | other | 1.6336 | 3 | hsa-miR-145-5p, hsa-miR-103a-3p, hsa-miR-328 |
| PPP2CB | protein phosphatase 2 catalytic subunit beta | Cytoplasm | phosphatase | 1.3771 | 6 | hsa-miR-218-5p, hsa-miR-425-5p, hsa-miR-143-3p, hsa-miR-151a-3p, hsa-miR-376c, hsa-miR-192-5p |
| PRDX3 | peroxiredoxin 3 | Cytoplasm | enzyme | 0.7113 | 1 | hsa-miR-543 |
| RETSAT | retinol saturase | Cytoplasm | enzyme | 1.3905 | 1 | hsa-miR-370 |
| RILPL2 | Rab interacting lysosomal protein like 2 | Cytoplasm | other | 2.2425 | 1 | hsa-miR-197-3p |
| RRAS2 | RAS related 2 | Plasma Membrane | enzyme | 1.7745 | 1 | hsa-miR-143-3p |
| S100A11 | S100 calcium binding protein A11 | Cytoplasm | other | 1.8678 | 1 | hsa-miR-143-3p |
| SLC7A1 | solute carrier family 7 member 1 | Plasma Membrane | transporter | 0.6433 | 1 | hsa-miR-592 |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 | Nucleus | transcription regulator | 1.4708 | 5 | hsa-miR-18a-5p, hsa-miR-99b-3p, hsa-miR-140-5p, hsa-miR-199a-3p, hsa-miR-1275 |
| THY1 | Thy-1 cell surface antigen | Plasma Membrane | other | 1.5111 | 3 | hsa-miR-143-3p, hsa-miR-193a-5p, hsa-miR-1275 |
| TLDC1 | TBC/LysM-associated domain containing 1 | Cytoplasm | other | 1.3989 | 2 | hsa-miR-202-3p, hsa-miR-135b-5p |
| TOR1AIP1 | torsin 1A interacting protein 1 | Nucleus | other | 1.4865 | 2 | hsa-miR-29b-1-5p, hsa-miR-192-5p |
| TUBA1A | tubulin alpha 1a | Cytoplasm | other | 1.8922 | 3 | hsa-miR-195-5p, hsa-miR-221-3p, hsa-miR-193a-5p |
| TUBB3 | tubulin beta 3 class III | Cytoplasm | other | 1.6204 | 1 | hsa-miR-15a-3p |
| TYMS | thymidylate synthetase | Nucleus | enzyme | 0.4859 | 1 | hsa-miR-935 |
| VAT1L | vesicle amine transport 1 like | Other | enzyme | 1.6315 | 5 | hsa-miR-18a-5p, hsa-miR-27a-3p, hsa-miR-671-3p, hsa-miR-30b-5p, hsa-miR-31-5p |
| XPO6 | exportin 6 | Cytoplasm | transporter | 1.5541 | 1 | hsa-miR-324-3p |