Table 2.
The expression of potential miRNA targets among VPA-proteins in primary culture activated HSCs.
| Symbol | A/Q sample1 | A/Q sample2 | A/Q sample3 | Avg Fold-Change (A/Q) | VPA/Control sample1 | VPA/Control sample2 | Avg Fold-Change (VPA/Control) |
|---|---|---|---|---|---|---|---|
| ALB* | 0.3467 | 0.3565 | 0.2355 | 0.3129 | 1.7670 | 1.3773 | 1.5721 |
| ALCAM* | 0.9550 | 0.6252 | 0.5649 | 0.7150 | 1.4134 | 1.4783 | 1.4458 |
| ANXA11* | 0.2938 | 0.3436 | 0.3664 | 0.3346 | 1.4344 | 1.4150 | 1.4247 |
| ANXA2 | 3.2211 | 4.8306 | 2.9376 | 3.6631 | 1.5408 | 2.0755 | 1.8081 |
| ANXA6 | 2.6546 | 1.5849 | 1.2246 | 1.8214 | 1.4260 | 1.4105 | 1.4183 |
| BAG3* | 29.6483 | 25.5859 | 19.9526 | 25.0623 | 0.6223 | 0.6830 | 0.6526 |
| BID* | 0.7727 | 0.7112 | 0.7047 | 0.7295 | 1.5109 | 1.3775 | 1.4442 |
| HMGA1* | 0.4656 | 0.3565 | 0.3048 | 0.3756 | 1.4812 | 2.8312 | 2.1562 |
| HNRNPA1 | 3.1333 | 0.9817 | 0.9638 | 1.6930 | 1.4239 | 1.3234 | 1.3736 |
| HNRNPA2B1* | 0.4446 | 0.4786 | 0.3802 | 0.4345 | 1.3695 | 1.6737 | 1.5216 |
| HSBP1 | 0.9908 | 2.8054 | 3.1046 | 2.3003 | 1.4016 | 1.4265 | 1.4140 |
| KRT10* | 0.6730 | 0.4055 | 0.6026 | 0.5603 | 2.7639 | 1.3759 | 2.0699 |
| LUC7L* | 1.1588 | 1.1588 | 0.7219 | 0.6758 | 0.6989 | ||
| MFAP1* | 1.2706 | 1.0765 | 1.0765 | 1.1412 | 0.6562 | 0.6659 | 0.6611 |
| NUP133* | 1.1272 | 1.1272 | 0.6554 | 0.6198 | 0.6376 | ||
| OS9 | 1.1482 | 1.1482 | 1.6046 | 1.6625 | 1.6336 | ||
| PPP2CB | 1.3062 | 1.3428 | 1.3305 | 1.3265 | 1.4420 | 1.3123 | 1.3771 |
| PRDX3* | 2.3121 | 2.5351 | 1.4723 | 2.1065 | 0.7178 | 0.7048 | 0.7113 |
| RRAS2* | 0.9638 | 0.6918 | 0.8278 | 2.1579 | 1.3911 | 1.7745 | |
| S100A11 | 20.8930 | 18.8799 | 1.5276 | 13.7668 | 1.8765 | 1.8591 | 1.8678 |
| SMARCC2* | 0.6730 | 0.6918 | 0.6546 | 0.6731 | 1.3328 | 1.6087 | 1.4708 |
| THY1 | 20.3236 | 11.1686 | 10.2802 | 13.9241 | 1.4926 | 1.5295 | 1.5111 |
| TOR1AIP1 | 1.0280 | 0.9727 | 1.0000 | 1.0003 | 1.4073 | 1.5658 | 1.4865 |
| TUBB3 | 19.2309 | 19.2309 | 1.4740 | 1.7668 | 1.6204 |
This table contains 24 out of the 46 potential miRNA targets among differentially expressed proteins in VPA treated LX2 cells that have been detected in primary HSCs. A/Q, fold-change of protein expression in primary culture activated rat HSCs (A) compared to quiescent rat HSCs (Q), with 3 biological repeats; VPA/Control, fold-change of protein expression in VPA treated LX2 cells (VPA) compared to untreated LX2 cells (Control), with 2 biological repeats.The protein expression data for primary culture activated HSCs were from a previous proteomics study 2.* Proteins showed opposite trend of expression in VPA treated HSCs compared to activated HSCs.