Table 1.
Exosomes and the formation of premetastatic niche
| Diseases | Exosomal moleculres | Type | Source cell | Target cell | Mechanisms | Reference |
|---|---|---|---|---|---|---|
| PDAC | MIF | protein | PDAC cells | macrophages | Fibrotic niche | 80 |
| BCa | miR-122 | miRNA | BCa cells | fibroblasts | Glucose metabolism niche | 92 |
| PC | miR-301a-3p | miRNA | PC cells | macrophages | Inflammatory niche | 93 |
| HCC | miR-103 | miRNA | Hepatoma cells | Endothelia | Angiogenesis niche | 94 |
| NPC | miR-23a | miRNA | NPC cells | endothelia | Angiogenesis niche | 95 |
| HCC | miR-1247-3p | miRNA | HCC cells | fibroblasts | Fibrotic niche | 96 |
| Gastric cancer | EGFR | protein | gastric cancer cells | stromal cells | Fibrotic niche | 97 |
| BCa | miR-23b | miRNA | MSCs | BCa cells | dormancy niche | 98 |
| HCC | miR-210 | miRNA | HCC cells | endothelial | Angiogenesis niche | 99 |
| Colon cancer | CEACAMs | protein | Colon cancer cells endothelial | T-cells | Immunosuppression niche | 100 |
Notes: PDAC: Pancreatic ductal adenocarcinomas; MIF: macrophage migration inhibitory factor; BCa: breast cancer; PC: pancreatic cancer; HCC: hepatocellular carcinoma.NPC:nasopharyngeal carcinoma;EGFR:epidermal growth factor receptor;MSC:mesenchymal stem cell; CEACAMs: carcinoembryonic antigen related cell adhesion molecules;