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. 2018 Dec 24;116(2):619–624. doi: 10.1073/pnas.1814027116

Fig. 1.

Fig. 1.

Distribution of somatic mutations. Each tumor was analyzed for somatic mutation burden and mutation type. Recurrent tumors also contained the highest non–synonymous-to-synonymous ratio of somatic mutations (3.59:1), followed by metastatic tumors (3.45:1) and primary tumors (3.23:1). For patients with two primary tumors, only the right tumor was included in this distribution.