Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Dec 24;116(2):619–624. doi: 10.1073/pnas.1814027116

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Published under the PNAS license.

PMC Copyright notice

Fig. 4. — GS-626510 and JQ1 inhibited cell proliferation in primary ovarian carcinoma cell lines in vitro and in ovarian cancer xenografts and PDXs in vivo. (A and B) IC₅₀ for GS-626510 and JQ1 of primary carcinoma cell lines incubated for 72 h with varying concentrations of GS-626510 and JQ1. (C and D) Tumor growth inhibition of OSC-KRCH31, a chemotherapy-resistant tumor cell line established from a patient experiencing progressive disease in vivo. (E) Tumor growth inhibition of OSC-OMM78, a chemotherapy-resistant PDX established from a patient experiencing progressive disease in vivo. (F) Overall survival of animals harboring OSC-OMM78 PDX and treated with GS-626510 vs. placebo control. *P < 0.05.