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. 2018 Dec 24;116(2):679–688. doi: 10.1073/pnas.1817455116

Fig. 2.

Fig. 2.

Overall and region-specific variation in different categories of amino acids of 26 orthologs of molluscan cMDHs as a function of enzyme stability (rate of denaturation at 40 °C for genus Haliotis, Adamussium colbecki, and Laternula elliptica and at 42.5 °C for all other species). The fitted linear regression line is shown as a solid line when P < 0.05; a dashed line is used when the regression was nonsignificant. Amino acid categories were charged (DEKR), weakly hydrophobic/polar (AGNQSTHY), and hydrophobic (LVWIFMPC) (33). (A–C) Overall variation in amino acid composition throughout the protein structure, (D–F) variation in surface composition, (G–I) variation in composition of the intermediate depth region, and (J–L) variation in composition of the core region of the protein. Variation in (M–P) proline and (Q–T) glycine content in different regions of the enzyme.