Fig. 3. Cytokine requirements for Th17 cell accumulation during experimental periodontitis.

(A-F) IL-17 production by CD4⁺ cells at baseline (CTL) and LIP. Bar graphs and FACS plots show numbers of Th17 cells at CTL and after LIP in Il6^−/− and Il6^+/+ mice (A-B), Il1r1^−/− and Il1r1^+/+ mice (C, D), Il23a^−/− and Il23a^+/+ mice (E-F). All data are representative of 2–3 separate experiments, n=6–8 for each group, p values determined by Mann-Whitney test, mean±SEM.