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. Author manuscript; available in PMC: 2019 May 12.
Published in final edited form as: Nat Genet. 2018 Nov 12;51(1):151–162. doi: 10.1038/s41588-018-0270-1

Figure 3. AML-specifically active cis-regulatory elements display AML type-specific transcription factor occupancy patterns.

Figure 3

(a) UCSC browser screen shot of the MDFI locus zooming in on an AML type-specific DHS (box) with occupied NFI, ETS and RUNX sites. (b) Heatmap depicting the degree of motif enrichment after hierarchical clustering of motif occupancy in each of the 20 AML DHS clusters. Enrichment score was calculated by the level of motif enrichment in all the footprints of all high read-depth samples for each cluster, as compared to union of footprints in all experiments.