Table 1.
Summary of control and sickle cell anemia participants.
| Adult Control participants (n=7) | Adult SCA participants (n=16) | Pediatric SCA participants (n=11) | |
|---|---|---|---|
| Demographic variables | |||
| Age (years) | 26.1 ± 6.2 | 24.6 ± 7.0 | 9.6 ± 2.7 |
| Sex (% Female) | 57 | 56 | 55 |
| Race (% Black) | 100 | 100 | 100 |
| Hematologic variables | |||
| Transfusion type (%) | |||
| Simple | - | 44 | 0 |
| Exchange | - | 56 | 100 |
| Indication for transfusion (%) | |||
| Secondary stroke prevention | - | 81 | 100 |
| Recurrent pain crisis | - | 25 | 9 |
| Anemia | - | 50 | 0 |
| Other | - | 6 | 0 |
| Imaging Timing (Days) | |||
| Time point 1 to Transfusion | - | 4.9 ± 19.8* | |
| Transfusion to Time point 2 | - | 2.1 ± 2.7 | |
| Hematocrit (%) | |||
| Time point 1 | 42.2 ± 6.8 | 24.8 ± 4.4 | 27.5 ± 3.2 |
| Time point 2 | - | 28.6 ± 4.2 | 33.4 ± 2.9 |
| Hemoglobin-S (%) | |||
| Time point 1 | 0 | 43.0 ± 10.3 | 39.1 ± 13.2 |
| Time point 2 | - | 26.2 ± 14.0 | 26.2 ± 13.2 |
| Neurologic variables | |||
| Overt Stroke (%) | 0 | 69 | 9 |
| Silent cerebral infarction (%) | 0 | 75 | 45 |
| Intracranial stenosis>50% (%) | 0 | 50 | 0 |
| Extracranial stenosis >50% (%)** | 0 | 20 | 0 |
*
one subject missed their subsequent transfusion cycle, resulting in a large variance for this measurement
**
Neck MRA was performed in 15 of 16 adults and 9 of 11 children