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. Author manuscript; available in PMC: 2020 Jan 12.
Published in final edited form as: AIDS. 2018 Jul 12:10.1097/QAD.0000000000001935. doi: 10.1097/QAD.0000000000001935

Figure 1. Schema for directly-observed administration of TDF/FTC and collection of hair samples from study participants.

Figure 1.

Blue bars indicate doses given during each randomized study arm. Intermittent doses were separated by days (e.g. 1 day on/2 days off for 33% intermittent dosing) and holiday doses were separated by weeks (e.g. 1 week on/2 weeks off for 33% holiday dosing). Gray bars represent ~6 weeks of hair growth (reflecting drug exposure over that time) prior to hair collection (indicated by red arrows). Hair was collected at weeks 4, 8, and 12 during dosing and every 3 weeks during a 12-week washout period. Following a 12-week washout period, participants received 12 additional weeks of a different dosing regimen and hair collection.