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. 2019 Jan 3;78(2):140–156. doi: 10.1093/jnen/nly121

FIGURE 11.

FIGURE 11.

AQP4-negative GFAP-positive astrocytes. Skip serial sections of an inactive late postphagocytic plaque (no LFB-positive or MBP-positive macrophages) in a patient with fulminant early MS (Case 3). (A, B) None of the numerous GFAP-positive stellate astrocytes present in the plaque is reactive for AQP4. (C, D) IgG-positive (C) and IgM-positive (D) astrocytes are indicative of an open blood-brain barrier. (E, F) MH2-positive inflammatory cells and macrophages are restricted largely to the perivascular cuff (E). This, and the paucity of MRP-positive monocytes (F), indicate a waning inflammatory milieu. (An inactive plaque in Case 3, disease duration 29 days). (A: GFAP; B: AQP4; C: IgG; D: IgM; E: MHC2; F: MRP14. A–F: ×115).