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Cerebral cortex—loss of protoplasmic astrocytes. (A) A magnified view of the lesion illustrated in Figure 17. Individual protoplasmic astrocytes show a loss of definition of their processes together with a reduction in AQP4 immunoreactivity. (B) The same area stained for microglia/macrophages shows small, ramified microglia present but no evidence of macrophage participation in the loss of protoplasmic astrocytes. (Case 2, A: AQP4, ×160; B: CD45, ×160).
