Figure 3.
Comparison of ADRB3-stimulated lipolysis in lean and obese male and female WAT and BAT depot explants. (A–C) FFA determination in lean and obese (A) GWAT, (B) IWAT, and (C) BAT explants. (D–F) FFA release calculated as fold change over basal conditions in lean and obese (D) GWAT, (E) IWAT, and (F) BAT explant tissues. n = 8 per group; error bars are SEM. *P < 0.05; **P < 0.01; ***P < 0.005; ****P < 0.0001. Comparisons of male ND PBS vs female ND PBS are shown as #P < 0.05 and ##P < 0.01, and male HFD PBS vs female HFD PBS are shown as &P < 0.05 and &&P < 0.01. Con, control; F, female; M, male.