Table 2.
Variables associated (p<0.1) with biochemical, endoscopic and histologic remission in Crohn’s disease.
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| Variables | P | OR | 95%CI | P | OR | 95%CI |
| A. Biochemical remission | ||||||
| ADM concentration ≥11.8 μg/ml | 0.007 | 4.3 | 1.5–11.9 | |||
| B. Endoscopic remission | ||||||
| Disease duration | 0.073 | |||||
| ADM dosing other than 40mg eow at time of TDM | 0.006 | 16 | 1.8–143.2 | |||
| ADM concentration ≥12 μg/rnL | 0.002 | 8.5 | 2.1–33.8 | 0.003 | 8 | 2–31.9 |
| C. Histologic remission | ||||||
| CD location | 0.064 | |||||
| Disease duration | 0.052 | |||||
| ADM dosing other than 40mg eow at time of TDM | 0.048 | 5.2 | 1.01–26.8 | |||
| ADM concentration ≥12.2 μg/ml | 0.009 | 8.5 | 1.6–45.9 | 0.012 | 9.6 | 1.7–56.1 |
OR: odds ratio; CI: confidence interval; ADM: adalimumab; CD: Crohn’s disease; eow: every other week; TDM: therapeutic drug monitoring.