. Author manuscript; available in PMC: 2019 Aug 1.

Published in final edited form as: Immunol Res. 2018 Aug;66(4):445–461. doi: 10.1007/s12026-018-9011-x

Table 1.

Localization of collagen and fibronectin in multiple sclerosis and control brains

Case number (age, sex)	Lesion (number)	Lesion type	Collagen 1		Collagen 2		Collagen 3		Collagen 4		Collagen 5		Fibronectin
			PA	V/PV	PA	V/PV	PA	V/PV	PA	V/PV	PA	V/PV	PA	V/PV
1 (53, F)	Occipital (3)	Plaque	++	++	++	++	+	+++	++	+++	++	+/++	++	++
		NAWM	++	++	++	+++	+/++	++/+++	−	++	++/+++	++	++	++
		NAGM	+++	++	+	+/++	+/++	++	−	+++	++	++	+++	++
	Parietal (1)	Plaque	+++	+++	+++	++	+++	+	+++	+++	++	++	+++	+++
2 (68, M)	Parietal (2)	Plaque	+++	+++	+	+	ND	ND	+++	+++	+++	+++	+++	+++
2 (68, M)	Parietal (2)	NAWM	++	+++	+++	+++	++	+++	+++	+++	+++	+++	++	+++
3 (62, M)	Parietal (3)	Plaque	+++	+++	++	++	+	++	++	+++	++	++	+	++
		NAWM	+	+++	ND	ND	++	+++	+	++	+	++	ND	ND
		NAGM	ND	ND	ND	ND	+++	+++	ND	ND	ND	ND	ND	ND
4 (38, F)	Frontal (2)	Plaque	+/++	++	++/+++	+++	+	++	++	+++	+	++	+	++
4 (38, F)	Frontal (2)	NAGM	ND	ND	ND	ND	+++	+	ND	ND	−	+	ND	ND
5 (47, F)	Parietal (2)	Plaque	+++	++	+	++	+	++	+	++/+++	+/++	++	++	++
	Parietal (2)	NAGM	ND	ND	ND	ND	+/++	+/++	ND	ND	+	+	ND	ND
	Frontal (3)	Plaque	++	+++	+	+++	+/++	+++	+++	+++	++	++	+	++
		NAWM	+	+	+/++	++	++	++/+++	−	+++	++	+/++	+	++
		NAGM	+ /−	++	ND	ND	++	+++	+	+++	+++	++	ND	ND
6 (50, M)	Temporal (2)	Plaque	+	++	+	++	+	++	+	++	+	+/++	+++	++
6 (50, M)	Temporal (2)	NAGM	+++	+	ND	ND	−	++	−	+	+	+	+++	+
7 (51, F)	Frontal (1)	Plaque	+/++	+++	++	+++	++	+++	+++	+++	+++	+++	++	+
8–13	Normal (8)	Control WM	−	+	−	+	−	+	−	+	−	+	ND	ND

F female, M male, NAWM normal-appearing white matter, NAGM normal-appearing gray matter, ND non-determined, − negative, + slightly positive, ++ positive, +++ highly positive, PA parenchymal, V/PV vascular/perivascular