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. 2019 Jan 7;9:684. doi: 10.3389/fgene.2018.00684

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Copyright © 2019 Knyazeva, Krutikov, Golovkin, Mishanin, Pavlov, Smolina, Hushkina, Sejersen, Sjoberg, Galagudza and Kostareva.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Morphological and molecular evidences of myocardial hypertrophy progression. (A) Immunohistochemical staining of beta- sarcoglycan allowing to detect outer membrane showing clear increase of cells size in transverse orientation by 10-weeks group compared to intact. (B) Increase in cell diameter (Dmin) illustrating progressive cardiomyocytes enlargement, and significant increase after 8 and 10 weeks of aortic banding performing. Nppa expression was upregulated in LV (C) and IVS (D) after 1, 2, 8, and 10 weeks of model duration compared to intact or sham-control groups. (E) Positive linear correlation was found for Nppa mRNA level and left ventricular mass (LVM) indexed to body weight. The analysis included experimental groups after 8 and 10 weeks of aortic constriction, 8 week’s sham-operated and intact animals, r indicates Pearson coefficient; for all ^∗P < 0.05.