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. 2019 Jan 7;9:3073. doi: 10.3389/fimmu.2018.03073

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Copyright © 2019 Lee, Kang, Lee and Quan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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T. gondii—specific IgG antibodies and neutralizing activity. T. gondii—specific IgG antibodies were induced after prime (A) and boost immunization (B, ^*P < 0.05). Sera neutralizing activity was determined using sera from VLPs immunized mice (C, ^*P < 0.01). Both sera from combination VLPs (TG1/TG4/TG6) and multi-antigen VLPs (TG146) significantly inhibited T. gondii (GT1) replication compared to PBS control and sera from naïve mice.