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. 2019 Jan 7;11:474. doi: 10.3389/fnmol.2018.00474

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Copyright © 2019 Zernii, Nazipova, Nemashkalova, Kazakov, Gancharova, Serebryakova, Tikhomirova, Baksheeva, Vladimirov, Zinchenko, Philippov, Senin and Permyakov.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histological analysis of posterior segments of the dark-adapted and illuminated in vivo rabbit eyes. Representative paraffin-embedded sections of the eye tissues were stained with hematoxylin and eosin (magnification 200×/400× on the inset; scale bar 20 μm). Designations are as follows: GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer; Ph, photoreceptor layer; RPE, retinal pigment epithelium; Scl, sclera. (A) Intact retina of a control dark-adapted animal. (B) The retina isolated immediately after illumination for 3 h with halogen lamp (30,000 lx). (C,D) The retina isolated 3 days after the light exposure. Macrophage-like cells in the space between RPE and the retina are indicated with white arrows. Retinal detachments from RPE are labeled with asterisks. Signs of karyopyknosis in ONL and changes in RPE are marked with red and yellow arrows, respectively (C, inset).