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. 2019 Jan 7;9:1510. doi: 10.3389/fphar.2018.01510

FIGURE 1.

FIGURE 1

Local application of puerarin attenuates mechanical allodynia and thermal hyperalgesia induced by paclitaxel (Ctrl, control; PTX, paclitaxel; Pue, puerarin). (A,B) Paclitaxel caused significant mechanical allodynia (A) and thermal hyperalgesia (B). n = 12 rats in each group. ∗∗P < 0.01, ∗∗∗P < 0.001 compared with the control group. (C) Puerarin dose-dependently relieved paclitaxel-induced mechanical allodynia (day 10). n = 18 rats in each group. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 compared with the paclitaxel + vehicle group (BL: baseline). (D) Puerarin dose-dependently relieved paclitaxel-induced thermal hyperalgesia (day 10). n = 12 rats in each group. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 compared with the paclitaxel + vehicle group (BL, baseline). (E) Motor performance was not changed after the local application of 10 μM puerarin. n = 10 rats in each group.