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. 2019 Jan 7;9:1510. doi: 10.3389/fphar.2018.01510

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Copyright © 2019 Zhang, Cao, Lai, Xie and Zeng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of puerarin on activation, inactivation and recovery of Na_v channels in DRG neurons at corresponding IC₅₀ concentrations (Ctrl, control; PTX, paclitaxel; Pue, puerarin). (A,B) Puerarin does not affect the activation curves of Na_v channels in control (A) and paclitaxel (day 10) (B) group (n = 10 neurons in each group). (C–F) The peak Na⁺ current (I_Na) was normalized to the maximal value (I_Na,max) and plotted against the conditioning pulse potential. The inactivation curves indicated that puerarin accelerated the inactivation of Na_v channels in two groups (n = 6–10 neurons in each group). (G,H) Puerarin slowed down the recovery from the inactivation of Na_v channels in each group (n = 10 neurons in each group). The detailed parameters of analysis are shown in Table 3.