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. 2019 Jan 7;9:1510. doi: 10.3389/fphar.2018.01510

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Copyright © 2019 Zhang, Cao, Lai, Xie and Zeng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of puerarin on TTX-R, TTX-S and Na_v1.8 channels in DRG neurons (Ctrl, control; PTX, paclitaxel; Pue, puerarin). (A) Representative traces of TTX-R currents recorded in the presence of TTX (300 nM) or TTX (300 nM) and puerarin (0.1μM). (B) TTX-S currents were recorded in the presence of A-803467 (1 μM), A-803467 (1 μM) and puerarin (0.01 μM) or TTX (300 nM). (C) IC₅₀ values of puerarin on resting TTX-R (n = 10 neurons in each data point) and TTX-S (n = 9 neurons in each data point) Na_v channels in DRG neurons of paclitaxel (day 10) rats. (D) IC₅₀ values of puerarin on inactivated TTX-R (n = 9 neurons in each data point) and TTX-S (n = 9 neurons in each data point) Na_v channels in DRG neurons of paclitaxel (day 10) rats. (E) The resting Na_v1.8 current traces were recorded before and 15 min after puerarin application at indicated concentrations. (F) The representative inactivated Na_v1.8 current traces were recorded before and 15 min after puerarin application at indicated concentrations. (G) IC₅₀ values of puerarin for resting Na_v1.8 in control and paclitaxel (day 10) groups. n = 10 neurons in each data point. (H) IC₅₀ values of puerarin for inactivated Na_v1.8 in control and paclitaxel (day 10) groups. n = 10 neurons in each data point.