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. 2019 Jan 7;9:1510. doi: 10.3389/fphar.2018.01510

Table 2.

The IC50 values in different models of DRG neurons.

Resting state Inactivated state
Ctrl 481.5 ± 61.7 μM 50.8 ± 6.4 μM
PTX 4.6 ± 0.6 μM 103.9 ± 11.7 nM
TTX-S 11.8 ± 1.6 μM 352.9 ± 39.1 nM
TTX-R 1.1 ± 0.2 μM 25.8 ± 3.1 nM
Ctrl Nav1.8 365.1 ± 37.3 μM 30.4 ± 3.2 μM
PTX Nav1.8 602.4 ± 59.6 nM 13.5 ± 1.4 nM
siRNA 279.7 ± 23.3 μM 18.6 ± 1.6 μM
Scramble 521.4 ± 53.2 nM 21.2 ± 2.5 nM