Table 3.
Parameters for Nav channels activation, inactivation, and recovery in DRG neurons.
| Activation |
Fast inactivation |
Slow inactivation |
Recovery |
|||||
|---|---|---|---|---|---|---|---|---|
| V0.5 | k | V0.5 | k | V0.5 | k | τ | ||
| Ctrl | Before Pue | –41.6 ± 1.2 | 5.1 ± 0.5 | –84.6 ± 0.3 | 5.3 ± 1.8 | 7.66 ± 0.1 | 20.72 ± 0.9 | 8.0 ± 0.5 |
| 500μM Pue | –43.7 ± 1.4 | 5.5 ± 0.6 | –92.2 ± 0.3∗∗ | 5.4 ± 0.1 | 2.12 ± 0.1∗ | 29.25 ± 1.4 | 12.3 ± 0.2∗∗∗ | |
| PTX | Before Pue | –36.6 ± 1.3 | 4.7 ± 0.4 | –75.2 ± 0.4 | 6.1 ± 1.2 | 15.08 ± 0.2 | 24.33 ± 1.1 | 6.3 ± 0.3 |
| 5μM Pue | –38.2 ± 1.6 | 4.8 ± 0.7 | –81.0 ± 1.7∗∗ | 7.0 ± 0.7 | –4.33 ± 0.1∗∗ | 27.22 ± 1.3 | 13.4 ± 0.2∗∗∗ | |
Mean values were derived from Boltzmann distribution of individual data sets as described in the Measures. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 vs. corresponding before Pue group.