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. 2019 Jan 7;9:1505. doi: 10.3389/fphar.2018.01505

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Copyright © 2019 Galvão, Queiroz-Junior, de Oliveira, Pinho, Hirsch and Teixeira.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of PI3K-γ or PI3K-δ inhibition on neutrophil accumulation and pro-inflammatory mediators production. Myeloperoxidase activity in homogenized periarticular tissue (A). IL-1β levels (B), CXCL1 (C), and TNF-α levels (D). Levels was measured by ELISA in supernatant of homogenized periarticular tissue. Results are expressed as the number of leukocytes per cavity and are shown as the mean ± SEM of five mice in each group from one experiment representative of two independent experiments. Significance was calculated using ANOVA followed by Holm-Sidak’s multiple comparison test. The exactly p-value are shown in the figure.