Skip to main content
. 2019 Jan 7;9:1505. doi: 10.3389/fphar.2018.01505

FIGURE 4.

FIGURE 4

Effects of delayed treatment of PI3K-γ or PI3K-δ inhibitor on tissue damage and hypernociceptive responses. Representative photographs of H&E-stained sections of knee from mice control (PBS), MSU challenge (MSU), mice challenge with MSU and post treated (12 h) with AS605240 (MSU+AS) and mice challenge with MSU and post treated (12 h) with GSK045 (MSU+GSK045) (bars represent 400 μm in magnification of 40× and 50 μm in magnification of 400×) (A). Graph shown histological score of joint injury of MSU crystal injected mice (B). Mechanical hypernociception was evaluated by an electronic pressure-meter 18 h after the injection of MSU crystals (100 μg; ia) treated or not with AS605240 or GSK045 (γ or δ – 50 μM i.a.) (C). Results are expressed as the number of leukocytes per cavity and are shown as the mean ± SEM of five mice in each group from one experiment representative of two independent experiments. Significance was calculated using ANOVA followed by Holm-Sidak’s multiple comparison test. The exactly p-value are shown in the figure.