Table 1.
List of pathways involved in ‘Carbohydrate metabolism’.
| Diseases or functions annotation | p-value | Predicted activation state | Activation z-score | Molecules | # Molecules |
|---|---|---|---|---|---|
| Gluconeogenesis | 0.0000000 | 0.343 | ACOT13, ALDH1A1, CRY1, FGF21, G6PC, GCK, IGFBP1, NR0B2, PPARA | 9 | |
| Concentration of D-glucose | 0.0000001 | 0.69 | ALDH1A1, CIDEA, ESR1, FGF21, FMO5, G6PC, GCK, GDF15, IGFBP1, Mt1, MYC, NR0B2, ONECUT1, PPARA, THRA | 15 | |
| Metabolism of D-glucose | 0.0000001 | 1 | G6PC, GCK, IGFBP1, MYC, ONECUT1, PPARA, SORD | 7 | |
| Synthesis of D-hexose | 0.0000023 | 1.735 | ALDH1A1, DUSP6, FGF21, GCK, MYC, PPARA, SORD | 7 | |
| Quantity of carbohydrate | 0.0000024 | Increased | 2.257 | ALDH1A1, CD14, CIDEA, ESR1, FGF21, FMO5, G6PC, GCK, GDF15, Gulo, IGFBP1, Mt1, MYC, NR0B2, ONECUT1, PPARA, THRA | 17 |
| Homeostasis of D-glucose | 0.0000017 | ACOT13, CIDEA, CRY1, FGF21, FMO5, G6PC, GCK, PPARA, SLC27A5, THRA | 10 | ||
| Transport of carbohydrate | 0.000010 | 0.478 | ABCC2, CD14, ESR1, FGF21, G6PC, GCK, MAP2K6, MYC, SLC1A2 | 9 | |
| Synthesis of D-glucose | 0.0000023 | 1.735 | ALDH1A1, DUSP6, FGF21, GCK, MYC, PPARA | 6 | |
| Quantity of glucose-6-phosphate | 0.000032 | G6PC, GCK, MYC | 3 | ||
| Regulation of D-glucose | 0.0000024 | FGF21, MYC, PPARA | 3 | ||
| Utilization of D-glucose | 0.000075 | GCK, MYC, PPARA, THRA | 4 | ||
| Transport of monosaccharide | 0.000119 | 0.555 | ESR1, FGF21, G6PC, GCK, MAP2K6, MYC, SLC1A2 | 7 | |
| Phosphorylation of D-glucose | 0.00021 | G6PC, GCK | 2 | ||
| Metabolism of glucose-6-phosphate | 0.0000057 | G6PC, GCK | 2 | ||
| Transport of D-glucose | 0.00044 | 0.555 | ESR1, FGF21, GCK, MAP2K6, MYC, SLC1A2 | 6 | |
| Quantity of glycogen | 0.0000100 | 1.172 | FGF21, G6PC, GCK, MYC, PPARA | 5 | |
| Synthesis of carbohydrate | 0.000583 | 1.809 | ALDH1A1, DUSP6, FGF2, G6PC, GCK, Gulo, IGFBP1, MYC, NR1D1, PPARA, SORD | 11 | |
| Gluconeogenesis of hepatocytes | 0.0000268 | ALDH1A1, NR0B2 | 2 | ||
| Import of D-glucose | 0.0014 | 0 | ESR1, FGF21, MYC, SLC1A2 | 4 | |
| Metabolism of carbohydrate | 0.0000320 | 1.483 | ALDH1A1, CYP2E1, DUSP6, FGF21, G6PC, GCK, Gulo, IGFBP1, MYC, NR1D1, ONECUT1, PPARA, SORD | 13 | |
| Uptake of carbohydrate | 0.00205 | 0.306 | ABCC2, CD14, FGF21, G6PC, GCK, MYC, PPARA, SLC1A2 | 8 | |
| Synthesis of glycogen | 0.0000560 | G6PC, GCK, IGFBP1, NR1D1 | 4 | ||
| Quantity of lactic acid | 0.00214 | GCK, MYC, PPARA | 3 | ||
| Production of lactic acid | 0.0000750 | GCK, MYC, PPARA | 3 |