Subject area	Biology, Endocrinology
More specific subject area	Metabolic regulation in the liver
Type of data	RNA-seq data tables and figures
How data were acquired	RNA-Sequencing, Ingenuity Pathway Analysis
Data format	Normalized, filtered and analyzed data; Bioinformatic prediction
Experimental factors	Liver transcriptome profile in Esr1 knockout (Esr1-/-) male rats
Experimental features	Liver tissues were collected from 10-week-old wild type and Esr1-/- male rats. Total RNA was isolated, and cDNA-libraries were prepared for RNA-sequencing. RNA-seq raw data reads were analyzed using CLC Genomics Workbench. Differentially expressed genes were further analyzed for their involvement in carbohydrate and lipid metabolism by IPA.
Data source location	A basic science laboratory at the University of Kansas Medical Center, Kansas City, KS, USA.
Data accessibility	Raw data have not yet been submitted to any public repository.
Related research article	V. Khristi, A. Ratri, S. Ghosh, S. Borosha, E. Dai, R. Roy, et al., Disruption of ESR1 alters the expression of genes regulating hepatic lipid and carbohydrate metabolism in male rats, Endocrinology (2018), Under review[1].