Figure 8.

Imatinib improved rheumatoid arthritis (RA) symptoms via the inhibition of colony‐stimulating factor receptor‐1 (CSF1R). (a) The knee‐joint lipoidal synovium and cartilage of rabbits were observed by haematoxylin and eosin (H&E) or toluidine blue staining, respectively. (b) Detection of tumour necrosis factor (TNF)‐α (inflammatory factor) and rheumatoid factor (RF) by enzyme‐linked immunosorbent assay. (c) Detection of anti‐CCP level and body weight loss. **P < 0·01 indicates statistical significance compared with the sham group. #P < 0·05 and ##P < 0·01 indicate statistical significance compared with the sterile saline (NC) group.