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. 2018 Nov 28;195(2):251–264. doi: 10.1111/cei.13226

Figure 3.

Figure 3

CD64 expression on circulating neutrophils correlates with Simple Endoscopic Score for Crohn’s Disease (SES‐CD). CD64 mean fluorescence intensity (MFI) on neutrophils (a) in blood of patients with active and inactive disease (Mann–Whitney U‐test), (b) in colon and blood of individuals with B1 versus non‐B1 disease, complete mucosal healing (n = 12) and healthy controls (healthy controls: colon samples: n = 10, blood samples n = 16) (Kruskal–Wallis followed by Dunn’s test between B1, B2 or B3, and healthy control groups (*), Wilcoxon matched‐pairs signed‐rank test for colonic versus circulating neutrophils (+) (healthy controls n = 10 paired samples). (c) Dot‐plot representing CD64 and CD66b co‐expression after gating on purified circulating and colonic neutrophils. (d) Correlations between CD64 MFI on circulating neutrophils and SES‐CD among the entire cohort (n = 73), exclusive colonic disease ‘L2’ (n = 42), B1 disease (n = 52) (Pearson’s correlation coefficient) *P < 0·05; **++P < 0·01; ***+++P < 0·001; ****++++P < 0·0001.