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. 2018 Nov 28;195(2):251–264. doi: 10.1111/cei.13226

Figure 4.

Figure 4

Expression of activation markers on mucosal and circulating neutrophils discriminates disease activity and severity in Crohn’s disease (CD) patients with B1 disease. (a) CD66b mean fluorescence intensity (MFI) on colonic neutrophils (left panel) and CD64 MFI on peripheral blood neutrophils (middle panel) according to the presence of complete mucosal healing [Simple Endoscopic Score for Crohn’s Disease (SES‐CD) ≥ 1: n = 43, SES‐CD = 0: n =12) (Mann–Whitney U‐test)]. Performance of each parameter to discriminate complete mucosal healing from individuals with SES‐CD ≥ 1 area under the curve (AUC) and their exact binomial confidence interval are presented as well as pairwise comparison of ROC curves (DeLong’s test) (right panel). (b) CD66b MFI on colonic neutrophils (left panel), CD64 MFI on circulating neutrophils (middle panel) and neutrophil activation power index (right panel) according to endoscopic disease severity in the subgroup with B1 disease (n = 40) (Kruskal–Wallis followed by Dunn’s test). *P < 0·05; **P < 0·01; ****P < 0·0001.