Table 2:

Maximum tolerated dose of blank acetalated dextran microparticles (Blank MPs), acetalated dextran microparticles encapsulating AR-12 (AR-12/MPs) and soluble AR-12. Sol = soluble

	Route
	Intranasal			Intravenous			Intraperitoneal
Formulation	Blank MPs	AR-12/MPs	Sol AR-12	Blank MPs	AR-12/MPs	Sol AR-12	Blank MPs	AR-12/MPs	Sol AR-12
Maximum tolerated AR-12 dose [mg/kg]	-	24	3	-	30	20	-	80*	80
Ace-DEX MPs [mg/kg]	170	140	-	470	190	-	1100*	1100*	-

^*Maximum particle suspendability [mg/kg]