Figure 5.

Apatinib reduced vessel density in INR1G9 subcutaneous tumors, but the hemorrhagic and necrotic areas showed no significant changes in tumors. (A) H&E staining of tumors. Scale bar, 200 μm. The full panorama of tumor in each group is at the right corner on each picture. Scale bar, 500 μm. (B) Quantitative analysis of the relative hemorrhagic regions (a) and necrotic regions (b) in (A). (C) Immunohistochemistry of Pecam1 in tumors, scale bar, 200 μm. (D) Quantitative analysis of positive rate of Pecam1 in tumors. Scale bar, 200 μm. Apa 50, apatinib 50 mg/kg; Apa 150, apatinib 150 mg/kg; Su 40, sunitinib 40 mg/kg.