Figure 7.

Apatinib inhibited metastases and vessel density in INR1G9 liver metastasis model. (A) Microscopic liver metastases were detected by H&E staining (upper panel) and immunohistochemistry staining of Pecam1 (lower panel) (n = 8). The areas of liver metastases were traced out by dotted lines at the edge of tumors. Scale bar, 200 μm. (B) Numbers of liver metastases in different groups as indicated. (C) Pecam1 expression levels in liver metastases in different groups as indicated. Apa 50, apatinib 50 mg/kg; Apa 150, apatinib 150 mg/kg; Su 40, sunitinib 40 mg/kg.