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. 2019 Jan 10;18:1176935118822804. doi: 10.1177/1176935118822804

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Distributions of average time to cure and sum dose of chemotherapy. (A): time, in simulation steps, to cure mutants versus the rank of each of 434 dose schedule parameter sets. (B): sum of lethal doses to cure mutants versus the rank of the each of the 434 dose schedule parameter sets. Points are color-coded according to the average time of 50 simulations that it takes to cure mutants, see Figure 3. (C): comparison of the ranks of parameter sets for the sum of doses and the ranks of the parameter sets for the time to cure. The ranks are not highly correlated (R² = 0.45).