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. 2019 Jan 10;18:1176935118822804. doi: 10.1177/1176935118822804

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Time to cure and accumulated dose for different dose schedules. (A) and (B): dose schedules for the shortest time to cure (two time-steps), and the slowest time to cure (263 time-steps), with the indicated parameter set of duration, interval, and lethality. The red arrows indicate the average times to cure for 50 simulations. (C) and (D): example of one of 50 simulations of the kinetics of the proportion of mutants per crypt for the dose schedules shown in (A) and (B), respectively. (E) and (F): total dose accumulation as a function of time-steps for the dose schedules shown in (A) and (B), respectively. The average total dose at the time of cure is indicated by the red line.